Dose-response relationships of ACE inhibitors and angiotensin II blockers

Details

Serval ID
serval:BIB_C552869D5287
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Dose-response relationships of ACE inhibitors and angiotensin II blockers
Journal
European Heart Journal
Author(s)
Brunner  H. R., Nussberger  J., Waeber  B.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
12/1994
Volume
15 Suppl D
Pages
123-8
Notes
Journal Article
Review --- Old month value: Dec
Abstract
It is difficult to establish dose-response relationships for ACE inhibitors in patients with hypertension or congestive heart failure. This has led to the widely held opinion that the effects of ACE inhibitors are hardly dose dependent. The purpose of this short discussion is to demonstrate that this class of compounds, as well as the more recent angiotensin II receptor antagonists, exhibit some very clear dose-response relationships when these are evaluated in normal volunteers based on the mechanisms for which they were designed. Characterization of these dose-response curves is important in order to use these drugs at their optimal dose and to obtain the maximal therapeutic benefit.
Keywords
Angiotensin II/*antagonists & inhibitors/physiology Angiotensin-Converting Enzyme Inhibitors/*administration & dosage/adverse effects Animals Dose-Response Relationship, Drug Heart Failure, Congestive/*drug therapy/physiopathology Hemodynamic Processes/drug effects/physiology Humans Hypertension/*drug therapy/physiopathology Receptors, Angiotensin/antagonists & inhibitors/physiology
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 15:40
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