Dose-response relationships of ACE inhibitors and angiotensin II blockers

Détails

ID Serval
serval:BIB_C552869D5287
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Dose-response relationships of ACE inhibitors and angiotensin II blockers
Périodique
European Heart Journal
Auteur⸱e⸱s
Brunner  H. R., Nussberger  J., Waeber  B.
ISSN
0195-668X (Print)
Statut éditorial
Publié
Date de publication
12/1994
Volume
15 Suppl D
Pages
123-8
Notes
Journal Article
Review --- Old month value: Dec
Résumé
It is difficult to establish dose-response relationships for ACE inhibitors in patients with hypertension or congestive heart failure. This has led to the widely held opinion that the effects of ACE inhibitors are hardly dose dependent. The purpose of this short discussion is to demonstrate that this class of compounds, as well as the more recent angiotensin II receptor antagonists, exhibit some very clear dose-response relationships when these are evaluated in normal volunteers based on the mechanisms for which they were designed. Characterization of these dose-response curves is important in order to use these drugs at their optimal dose and to obtain the maximal therapeutic benefit.
Mots-clé
Angiotensin II/*antagonists & inhibitors/physiology Angiotensin-Converting Enzyme Inhibitors/*administration & dosage/adverse effects Animals Dose-Response Relationship, Drug Heart Failure, Congestive/*drug therapy/physiopathology Hemodynamic Processes/drug effects/physiology Humans Hypertension/*drug therapy/physiopathology Receptors, Angiotensin/antagonists & inhibitors/physiology
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 15:40
Données d'usage