Delayed B-cell maturation and attenuated vaccine responses in infants exposed to B-cell depleting therapies in utero.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C2B7DF829581
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Delayed B-cell maturation and attenuated vaccine responses in infants exposed to B-cell depleting therapies in utero.
Journal
The journal of allergy and clinical immunology. In practice
Author(s)
Soomann M., Prader S., Carlomagno R., Pachlopnik Schmid J., Trück J.
ISSN
2213-2201 (Electronic)
Publication state
Published
Issued date
11/2024
Peer-reviewed
Oui
Volume
12
Number
11
Pages
3155-3158.e1
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In utero exposure to anti-CD20 monoclonal antibodies can result in transient B-cell depletion, delayed B-cell maturation, decreased immunoglobulin production and inadequate vaccine responses in the infant. These children require immunological follow up and personalized vaccine schedules.
Keywords
Krec, in utero exposure, kappa-deleting recombination excision circles, neonatal screening, obinutuzumab, rituximab, vaccine responses, KREC
URN
urn:nbn:ch:serval-BIB_C2B7DF8295813
OAI-PMH
oai:serval.unil.ch:BIB_C2B7DF829581
DOI
10.1016/j.jaip.2024.08.007
Pubmed
39127106
Open Access
Yes
Create date
19/08/2024 8:20
Last modification date
20/11/2024 7:27
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