Commentary: Priming of alloreactive T cells--where does it happen?
Details
Serval ID
serval:BIB_C27A065C3C51
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Commentary: Priming of alloreactive T cells--where does it happen?
Journal
European Journal of Immunology
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
12/2004
Volume
34
Number
12
Pages
3301-4
Notes
Comment
Journal Article --- Old month value: Dec
Journal Article --- Old month value: Dec
Abstract
Host lymphocytes can recognize alloantigens directly on transplanted donor tissue or indirectly after these antigens are processed and presented on host APC. Here, we outline the features of alloresponses that distinguish them from responses to conventional antigens, then we discuss various study systems that have examined where the priming of alloreactive CD4(+) and CD8(+) T cells occurs. Finally, we discuss the implications of recent data which suggest that direct responses originate in the graft itself whereas indirect responses are initiated in the draining lymph nodes.
Keywords
Animals
Antigen Presentation
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Graft Rejection/immunology
Isoantigens/*immunology
Mice
Mice, Transgenic
*Organ Transplantation
Receptors, Antigen, T-Cell/genetics/immunology
T-Lymphocyte Subsets/*immunology
*Transplantation Immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:45
Last modification date
20/08/2019 16:37