Commentary: Priming of alloreactive T cells--where does it happen?
Détails
ID Serval
serval:BIB_C27A065C3C51
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
Commentary: Priming of alloreactive T cells--where does it happen?
Périodique
European Journal of Immunology
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
12/2004
Volume
34
Numéro
12
Pages
3301-4
Notes
Comment
Journal Article --- Old month value: Dec
Journal Article --- Old month value: Dec
Résumé
Host lymphocytes can recognize alloantigens directly on transplanted donor tissue or indirectly after these antigens are processed and presented on host APC. Here, we outline the features of alloresponses that distinguish them from responses to conventional antigens, then we discuss various study systems that have examined where the priming of alloreactive CD4(+) and CD8(+) T cells occurs. Finally, we discuss the implications of recent data which suggest that direct responses originate in the graft itself whereas indirect responses are initiated in the draining lymph nodes.
Mots-clé
Animals
Antigen Presentation
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Graft Rejection/immunology
Isoantigens/*immunology
Mice
Mice, Transgenic
*Organ Transplantation
Receptors, Antigen, T-Cell/genetics/immunology
T-Lymphocyte Subsets/*immunology
*Transplantation Immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:45
Dernière modification de la notice
20/08/2019 16:37