Performance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysis.

Détails

Ressource 1Télécharger: 26243791AM.pdf (791.50 [Ko])
Etat: Serval
Version: Author's accepted manuscript
Document(s) secondaire(s)
Télécharger: N-O-D-15-00235R1-FET FDG metaanalysis-final.2.pdf (60.94 [Ko])
Etat: Serval
Version: Supplementary document
ID Serval
serval:BIB_C1621CCB076D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Performance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysis.
Périodique
Neuro-oncology
Auteur(s)
Dunet V., Pomoni A., Hottinger A., Nicod-Lalonde M., Prior J.O.
ISSN
1523-5866 (Electronic)
ISSN-L
1522-8517
Statut éditorial
Publié
Date de publication
03/2016
Peer-reviewed
Oui
Volume
18
Numéro
3
Pages
426-434
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review

Résumé
For the past decade (18)F-fluoro-ethyl-l-tyrosine (FET) and (18)F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) have been used for the assessment of patients with brain tumor. However, direct comparison studies reported only limited numbers of patients. Our purpose was to compare the diagnostic performance of FET and FDG-PET.
We examined studies published between January 1995 and January 2015 in the PubMed database. To be included the study should: (i) use FET and FDG-PET for the assessment of patients with isolated brain lesion and (ii) use histology as the gold standard. Analysis was performed on a per patient basis. Study quality was assessed with STARD and QUADAS criteria.
Five studies (119 patients) were included. For the diagnosis of brain tumor, FET-PET demonstrated a pooled sensitivity of 0.94 (95% CI: 0.79-0.98) and pooled specificity of 0.88 (95% CI: 0.37-0.99), with an area under the curve of 0.96 (95% CI: 0.94-0.97), a positive likelihood ratio (LR+) of 8.1 (95% CI: 0.8-80.6), and a negative likelihood ratio (LR-) of 0.07 (95% CI: 0.02-0.30), while FDG-PET demonstrated a sensitivity of 0.38 (95% CI: 0.27-0.50) and specificity of 0.86 (95% CI: 0.31-0.99), with an area under the curve of 0.40 (95% CI: 0.36-0.44), an LR+ of 2.7 (95% CI: 0.3-27.8), and an LR- of 0.72 (95% CI: 0.47-1.11). Target-to-background ratios of either FDG or FET, however, allow distinction between low- and high-grade gliomas (P > .11).
For brain tumor diagnosis, FET-PET performed much better than FDG and should be preferred when assessing a new isolated brain tumor. For glioma grading, however, both tracers showed similar performances.

Mots-clé
Brain Neoplasms/classification, Brain Neoplasms/diagnostic imaging, Brain Neoplasms/pathology, Fluorodeoxyglucose F18, Glioma/diagnostic imaging, Glioma/pathology, Humans, Neoplasm Grading, Positron-Emission Tomography/methods, Radiopharmaceuticals, 18F-fluoro-deoxy-glucose, 18F-fluoro-ethyl-tyrosine, PET, brain tumor, meta-analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2015 15:36
Dernière modification de la notice
09/05/2019 0:45
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