Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.

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Serval ID
serval:BIB_BE964606C7DC
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
UNIL/CHUV
Title
Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Author(s)
Aubry-Rozier B., Gonzalez-Rodriguez E., Stoll D., Lamy O.
ISSN
1433-2965 (Electronic)
ISSN-L
0937-941X
Publication state
Published
Issued date
05/2016
Peer-reviewed
Oui
Volume
27
Number
5
Pages
1923-1925
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Osteoporosis treatments are usually given for a limited period of time in order to balance benefits and risks. We report three cases of postmenopausal women without any previous fragility fracture who presented severe spontaneous vertebral fractures after denosumab discontinuation. We think that the occurrence of these fractures could be explained by the severe rebound effect observed after denosumab discontinuation and that a consensus regarding the end of treatment with denosumab has to be defined.

Keywords
Aged, Bone Density Conservation Agents/administration & dosage, Bone Density Conservation Agents/therapeutic use, Denosumab/administration & dosage, Denosumab/therapeutic use, Drug Administration Schedule, Female, Fractures, Spontaneous/etiology, Fractures, Spontaneous/prevention & control, Humans, Middle Aged, Osteoporosis, Postmenopausal/complications, Osteoporosis, Postmenopausal/drug therapy, Osteoporotic Fractures/etiology, Osteoporotic Fractures/prevention & control, Spinal Fractures/etiology, Spinal Fractures/prevention & control, Withholding Treatment
OAI-PMH
oai:serval.unil.ch:BIB_BE964606C7DC
DOI
10.1007/s00198-015-3380-y
Pubmed
26510845
Create date
28/12/2015 13:41
Last modification date
20/08/2019 15:32
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