Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.

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ID Serval
serval:BIB_BE964606C7DC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
UNIL/CHUV
Titre
Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.
Périodique
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Auteur⸱e⸱s
Aubry-Rozier B., Gonzalez-Rodriguez E., Stoll D., Lamy O.
ISSN
1433-2965 (Electronic)
ISSN-L
0937-941X
Statut éditorial
Publié
Date de publication
05/2016
Peer-reviewed
Oui
Volume
27
Numéro
5
Pages
1923-1925
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Osteoporosis treatments are usually given for a limited period of time in order to balance benefits and risks. We report three cases of postmenopausal women without any previous fragility fracture who presented severe spontaneous vertebral fractures after denosumab discontinuation. We think that the occurrence of these fractures could be explained by the severe rebound effect observed after denosumab discontinuation and that a consensus regarding the end of treatment with denosumab has to be defined.

Mots-clé
Aged, Bone Density Conservation Agents/administration & dosage, Bone Density Conservation Agents/therapeutic use, Denosumab/administration & dosage, Denosumab/therapeutic use, Drug Administration Schedule, Female, Fractures, Spontaneous/etiology, Fractures, Spontaneous/prevention & control, Humans, Middle Aged, Osteoporosis, Postmenopausal/complications, Osteoporosis, Postmenopausal/drug therapy, Osteoporotic Fractures/etiology, Osteoporotic Fractures/prevention & control, Spinal Fractures/etiology, Spinal Fractures/prevention & control, Withholding Treatment
OAI-PMH
oai:serval.unil.ch:BIB_BE964606C7DC
DOI
10.1007/s00198-015-3380-y
Pubmed
26510845
Création de la notice
28/12/2015 13:41
Dernière modification de la notice
20/08/2019 15:32
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