Article: article from journal or magazin.
An autosomal recessive gene that delays expression of lupus in BXSB mice
Journal of Immunology
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb 15
We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autosomal recessive gene. This putative gene, referred to as ll (long-lived), causes a significant delay in expression of autoimmune serology (total serum IgG and anti-nuclear antibodies levels), monocytosis, and of immune complex-mediated histopathologic changes such as glomerulonephritis, arteritis, and myocardial infarction. Presumably as a consequence of the delayed immunopathology male BXSB/MpJScr-ll/ll mice live three to four times longer than regular BXSB/MpJScr. This strain might be useful for analysis of single genes responsible for severe autoimmune disease expression.
Animals DNA, Viral/analysis Disease Models, Animal Genes, Recessive/physiology Genetic Predisposition to Disease Life Expectancy Lupus Erythematosus, Systemic/*genetics/immunology/pathology Male Mice Mice, Inbred Strains Retroviridae/genetics
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