An autosomal recessive gene that delays expression of lupus in BXSB mice

Détails

ID Serval
serval:BIB_BE42682E47DA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
An autosomal recessive gene that delays expression of lupus in BXSB mice
Périodique
Journal of Immunology
Auteur(s)
Kofler  R., McConahey  P. J., Duchosal  M. A., Balderas  R. S., Theofilopoulos  A. N., Dixon  F. J.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
02/1991
Volume
146
Numéro
4
Pages
1375-1379
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb 15
Résumé
We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autosomal recessive gene. This putative gene, referred to as ll (long-lived), causes a significant delay in expression of autoimmune serology (total serum IgG and anti-nuclear antibodies levels), monocytosis, and of immune complex-mediated histopathologic changes such as glomerulonephritis, arteritis, and myocardial infarction. Presumably as a consequence of the delayed immunopathology male BXSB/MpJScr-ll/ll mice live three to four times longer than regular BXSB/MpJScr. This strain might be useful for analysis of single genes responsible for severe autoimmune disease expression.
Mots-clé
Animals DNA, Viral/analysis Disease Models, Animal Genes, Recessive/physiology Genetic Predisposition to Disease Life Expectancy Lupus Erythematosus, Systemic/*genetics/immunology/pathology Male Mice Mice, Inbred Strains Retroviridae/genetics
Pubmed
Web of science
Création de la notice
25/01/2008 16:24
Dernière modification de la notice
20/08/2019 16:32
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