Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.
Details
State: Public
Version: author
Serval ID
serval:BIB_BCDB78CE284B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.
Journal
Bone
ISSN
1873-2763 (Electronic)
ISSN-L
1873-2763
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
78
Pages
216-224
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX® algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g., diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX.
Keywords
Absorptiometry, Photon, Adult, Aged, Algorithms, Bone Density, Bone and Bones/physiopathology, Bone and Bones/radiography, Cross-Sectional Studies, Cushing Syndrome/complications, Diabetes Mellitus, Type 2/complications, Female, Femur/pathology, Fracture Healing, Humans, Hyperparathyroidism, Primary/complications, Lumbar Vertebrae/pathology, Male, Middle Aged, Osteoarthritis/complications, Osteoporosis/diagnosis, Osteoporosis/physiopathology, Osteoporosis, Postmenopausal/diagnosis, Osteoporosis, Postmenopausal/physiopathology, Osteoporotic Fractures/diagnosis, Osteoporotic Fractures/physiopathology, Probability, Risk Assessment, Risk Factors
Pubmed
Web of science
Create date
13/07/2015 9:22
Last modification date
20/08/2019 16:30