Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression.

Details

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State: Public
Version: Final published version
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Serval ID
serval:BIB_BC3BEEC76FE9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression.
Journal
British journal of cancer
Author(s)
Combaret V., Gross N., Lasset C., Balmas K., Bouvier R., Frappaz D., Beretta-Brognara C., Philip T., Favrot M.C., Coll J.L.
ISSN
0007-0920
ISSN-L
0007-0920
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
75
Number
8
Pages
1151-1155
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
TRKA expression was evaluated on 122 untreated neuroblastomas by immunohistochemistry using an antibody with predetermined specificity. This procedure is simple and reliable for protein detection at cellular level in a routine clinical setting. Fourteen tumours were classified as benign ganglioneuroma with a restricted expression of TRKA on ganglion cells; these patients were excluded from the following analysis. A total of 108 tumours were classified as neuroblastoma or ganglioneuroblastoma; 74 expressed TRKA protein, which strongly correlated with low stage, absence of N-MYC amplification, age (<1 year), CD44 expression and favourable clinical outcome. In a univariate analysis including tumour stage, age, histology, N-MYC amplification, CD44 and TRKA expression, all parameters had significant prognostic value. The absence of TRKA expression on CD44-positive or N-MYC non-amplified tumours permits the characterization of a subgroup of patients with intermediate prognosis. However, in a multivariate analysis taking into consideration the prognostic factors mentioned above, CD44 and tumour stage were the only independent prognostic factors for the prediction of patients' event-free survival.
Keywords
Analysis of Variance, Blotting, Southern, Disease-Free Survival, Ganglioneuroma/genetics, Ganglioneuroma/metabolism, Ganglioneuroma/pathology, Gene Amplification, Genes, myc/genetics, Humans, Hyaluronan Receptors/biosynthesis, Immunoenzyme Techniques, Infant, Neuroblastoma/genetics, Neuroblastoma/metabolism, Neuroblastoma/pathology, Prognosis, Proto-Oncogene Proteins/biosynthesis, Proto-Oncogene Proteins c-myc/genetics, Receptor Protein-Tyrosine Kinases/biosynthesis, Receptor, trkA, Receptors, Nerve Growth Factor/biosynthesis
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2008 16:55
Last modification date
09/08/2024 15:52
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