Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression

Détails

ID Serval
serval:BIB_BC3BEEC76FE9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression
Périodique
British Journal of Cancer
Auteur(s)
Combaret  V., Gross  N., Lasset  C., Balmas  K., Bouvier  R., Frappaz  D., Beretta-Brognara  C., Philip  T., Favrot  M. C., Coll  J. L.
ISSN
0007-0920
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
75
Numéro
8
Pages
1151-5
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Résumé
TRKA expression was evaluated on 122 untreated neuroblastomas by immunohistochemistry using an antibody with predetermined specificity. This procedure is simple and reliable for protein detection at cellular level in a routine clinical setting. Fourteen tumours were classified as benign ganglioneuroma with a restricted expression of TRKA on ganglion cells; these patients were excluded from the following analysis. A total of 108 tumours were classified as neuroblastoma or ganglioneuroblastoma; 74 expressed TRKA protein, which strongly correlated with low stage, absence of N-MYC amplification, age (<1 year), CD44 expression and favourable clinical outcome. In a univariate analysis including tumour stage, age, histology, N-MYC amplification, CD44 and TRKA expression, all parameters had significant prognostic value. The absence of TRKA expression on CD44-positive or N-MYC non-amplified tumours permits the characterization of a subgroup of patients with intermediate prognosis. However, in a multivariate analysis taking into consideration the prognostic factors mentioned above, CD44 and tumour stage were the only independent prognostic factors for the prediction of patients' event-free survival.
Mots-clé
Analysis of Variance Antigens, CD44/*biosynthesis Blotting, Southern Disease-Free Survival Ganglioneuroma/genetics/metabolism/pathology *Gene Amplification Genes, myc/genetics Humans Immunoenzyme Techniques Infant Neuroblastoma/genetics/*metabolism/pathology Prognosis Proto-Oncogene Proteins/*biosynthesis Proto-Oncogene Proteins c-myc/*genetics Receptor Protein-Tyrosine Kinases/*biosynthesis Receptor, trkA Receptors, Nerve Growth Factor/*biosynthesis
Pubmed
Web of science
Création de la notice
20/01/2008 16:55
Dernière modification de la notice
20/08/2019 16:30
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