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PPAR gamma: an essential role in metabolic control.
Nutrition, Metabolism, and Cardiovascular Diseases
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.
Adipose Tissue/metabolism, Animals, Arteriosclerosis/etiology, Gene Expression, Humans, Inflammation/etiology, Insulin/physiology, Ligands, Prostaglandin D2/analogs & derivatives, Prostaglandin D2/analysis, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/metabolism, Thiazoles, Thiazolidinediones, Transcription Factors/genetics, Transcription Factors/metabolism
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