PPAR gamma: an essential role in metabolic control.
Details
Serval ID
serval:BIB_BBA12A0D8601
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
PPAR gamma: an essential role in metabolic control.
Journal
Nutrition, Metabolism, and Cardiovascular Diseases
ISSN
0939-4753 (Print)
ISSN-L
0939-4753
Publication state
Published
Issued date
2001
Volume
11
Number
1
Pages
64-69
Language
english
Abstract
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.
Keywords
Adipose Tissue/metabolism, Animals, Arteriosclerosis/etiology, Gene Expression, Humans, Inflammation/etiology, Insulin/physiology, Ligands, Prostaglandin D2/analogs & derivatives, Prostaglandin D2/analysis, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/metabolism, Thiazoles, Thiazolidinediones, Transcription Factors/genetics, Transcription Factors/metabolism
Pubmed
Web of science
Create date
07/03/2013 17:07
Last modification date
20/08/2019 16:29
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