Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.

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Version: Final published version
Serval ID
serval:BIB_BB277D188C2B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.
Journal
Scientific Reports
Author(s)
Kujala J., Jung J., Bouvard S., Lecaignard F., Lothe A., Bouet R., Ciumas C., Ryvlin P., Jerbi K.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
5
Pages
16347
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
High-frequency oscillations in the gamma-band reflect rhythmic synchronization of spike timing in active neural networks. The modulation of gamma oscillations is a widely established mechanism in a variety of neurobiological processes, yet its neurochemical basis is not fully understood. Modeling, in-vitro and in-vivo animal studies suggest that gamma oscillation properties depend on GABAergic inhibition. In humans, search for evidence linking total GABA concentration to gamma oscillations has led to promising -but also to partly diverging- observations. Here, we provide the first evidence of a direct relationship between the density of GABA(A) receptors and gamma oscillatory gamma responses in human primary visual cortex (V1). By combining Flumazenil-PET (to measure resting-levels of GABA(A) receptor density) and MEG (to measure visually-induced gamma oscillations), we found that GABA(A) receptor densities correlated positively with the frequency and negatively with amplitude of visually-induced gamma oscillations in V1. Our findings demonstrate that gamma-band response profiles of primary visual cortex across healthy individuals are shaped by GABA(A)-receptor-mediated inhibitory neurotransmission. These results bridge the gap with in-vitro and animal studies and may have future clinical implications given that altered GABAergic function, including dysregulation of GABA(A) receptors, has been related to psychiatric disorders including schizophrenia and depression.
Keywords
Adult, Female, Flumazenil/chemistry, Humans, Magnetic Resonance Imaging, Magnetoencephalography, Male, Positron-Emission Tomography, Receptors, GABA-A/metabolism, Visual Cortex/metabolism, gamma-Aminobutyric Acid/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
08/12/2015 18:45
Last modification date
20/08/2019 15:29
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