Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_BB277D188C2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.
Périodique
Scientific Reports
Auteur(s)
Kujala J., Jung J., Bouvard S., Lecaignard F., Lothe A., Bouet R., Ciumas C., Ryvlin P., Jerbi K.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
5
Pages
16347
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
High-frequency oscillations in the gamma-band reflect rhythmic synchronization of spike timing in active neural networks. The modulation of gamma oscillations is a widely established mechanism in a variety of neurobiological processes, yet its neurochemical basis is not fully understood. Modeling, in-vitro and in-vivo animal studies suggest that gamma oscillation properties depend on GABAergic inhibition. In humans, search for evidence linking total GABA concentration to gamma oscillations has led to promising -but also to partly diverging- observations. Here, we provide the first evidence of a direct relationship between the density of GABA(A) receptors and gamma oscillatory gamma responses in human primary visual cortex (V1). By combining Flumazenil-PET (to measure resting-levels of GABA(A) receptor density) and MEG (to measure visually-induced gamma oscillations), we found that GABA(A) receptor densities correlated positively with the frequency and negatively with amplitude of visually-induced gamma oscillations in V1. Our findings demonstrate that gamma-band response profiles of primary visual cortex across healthy individuals are shaped by GABA(A)-receptor-mediated inhibitory neurotransmission. These results bridge the gap with in-vitro and animal studies and may have future clinical implications given that altered GABAergic function, including dysregulation of GABA(A) receptors, has been related to psychiatric disorders including schizophrenia and depression.
Mots-clé
Adult, Female, Flumazenil/chemistry, Humans, Magnetic Resonance Imaging, Magnetoencephalography, Male, Positron-Emission Tomography, Receptors, GABA-A/metabolism, Visual Cortex/metabolism, gamma-Aminobutyric Acid/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/12/2015 19:45
Dernière modification de la notice
20/08/2019 16:29
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