Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_B5C359953C66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.
Journal
Emerging infectious diseases
Author(s)
Nahimana A., Rabodonirina M., Helweg-Larsen J., Meneau I., Francioli P., Bille J., Hauser P.M.
ISSN
1080-6040
ISSN-L
1080-6040
Publication state
Published
Issued date
07/2003
Peer-reviewed
Oui
Volume
9
Number
7
Pages
864-867
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Keywords
Adult, Anti-Infective Agents/pharmacology, DNA, Fungal/analysis, Dihydropteroate Synthase/genetics, Dihydropteroate Synthase/metabolism, Drug Resistance, Fungal/genetics, Female, Genotype, Humans, Male, Middle Aged, Mutation/genetics, Pneumocystis/drug effects, Pneumocystis/genetics, Pneumonia, Pneumocystis/drug therapy, Pneumonia, Pneumocystis/microbiology, Recurrence, Sulfonamides/pharmacology, Sulfones/pharmacology
DOI
10.3201/eid0907.030249
Pubmed
12890330
Web of science
000184022300018
Open Access
Yes
Create date
25/01/2008 17:07
Last modification date
07/08/2024 10:24
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