Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.

Détails

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ID Serval
serval:BIB_B5C359953C66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Production externe
Titre
Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.
Périodique
Emerging infectious diseases
Auteur⸱e⸱s
Nahimana A., Rabodonirina M., Helweg-Larsen J., Meneau I., Francioli P., Bille J., Hauser P.M.
ISSN
1080-6040
ISSN-L
1080-6040
Statut éditorial
Publié
Date de publication
07/2003
Peer-reviewed
Oui
Volume
9
Numéro
7
Pages
864-867
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Mots-clé
Adult, Anti-Infective Agents/pharmacology, DNA, Fungal/analysis, Dihydropteroate Synthase/genetics, Dihydropteroate Synthase/metabolism, Drug Resistance, Fungal/genetics, Female, Genotype, Humans, Male, Middle Aged, Mutation/genetics, Pneumocystis/drug effects, Pneumocystis/genetics, Pneumonia, Pneumocystis/drug therapy, Pneumonia, Pneumocystis/microbiology, Recurrence, Sulfonamides/pharmacology, Sulfones/pharmacology
DOI
10.3201/eid0907.030249
Pubmed
12890330
Web of science
000184022300018
Open Access
Oui
Création de la notice
25/01/2008 18:07
Dernière modification de la notice
28/06/2024 10:09
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