Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
Détails
ID Serval
serval:BIB_B5C359953C66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
Périodique
Emerging Infectious Diseases
ISSN
1080-6040 (Print)
Statut éditorial
Publié
Date de publication
07/2003
Volume
9
Numéro
7
Pages
864-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Mots-clé
Adult
Anti-Infective Agents/pharmacology
DNA, Fungal/analysis
Dihydropteroate Synthase/*genetics/metabolism
Drug Resistance, Fungal/*genetics
Female
Genotype
Humans
Male
Middle Aged
Mutation/*genetics
Pneumocystis/drug effects/*genetics
Pneumonia, Pneumocystis/drug therapy/*microbiology
Recurrence
Sulfonamides/*pharmacology
Sulfones/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 18:07
Dernière modification de la notice
16/07/2021 16:32
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