Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia

Details

Serval ID
serval:BIB_B5C359953C66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
Journal
Emerging Infectious Diseases
Author(s)
Nahimana  A., Rabodonirina  M., Helweg-Larsen  J., Meneau  I., Francioli  P., Bille  J., Hauser  P. M.
ISSN
1080-6040 (Print)
Publication state
Published
Issued date
07/2003
Volume
9
Number
7
Pages
864-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Keywords
Adult Anti-Infective Agents/pharmacology DNA, Fungal/analysis Dihydropteroate Synthase/*genetics/metabolism Drug Resistance, Fungal/*genetics Female Genotype Humans Male Middle Aged Mutation/*genetics Pneumocystis/drug effects/*genetics Pneumonia, Pneumocystis/drug therapy/*microbiology Recurrence Sulfonamides/*pharmacology Sulfones/*pharmacology
Pubmed
Web of science
Create date
25/01/2008 17:07
Last modification date
20/08/2019 15:24
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