FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.

Details

Serval ID
serval:BIB_B4F1E1A64EA0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.
Journal
Physica medica
Author(s)
Stephan F., Gross M., Grebinyk A., Aboulbanine Z., Amirkhanyan Z., Budach V., Ehrhardt V.H., Faus-Golfe A., Frohme M., Germond J.F., Good J.D., Grüner F., Kaul D., Krasilnikov M., Leavitt R., Leemans W., Li X., Loisch G., Müller F., Müller G., Obier F., Oppelt A., Philipp S., Qian H., Reindl J., Riemer F., Sack M., Schmitz M., Schnautz T., Schüller A., Staufer T., Stegmann C., Tsakanova G., Vozenin M.C., Weise H., Worm S., Zips D.
ISSN
1724-191X (Electronic)
ISSN-L
1120-1797
Publication state
Published
Issued date
12/2022
Peer-reviewed
Oui
Volume
104
Pages
174-187
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 10 <sup>14</sup> Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a "painting" with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.
Keywords
Humans, Electrons, Radiobiology, Neoplasms, FLASH and VHEE radiation therapy, Flexible electron accelerator, Online image guiding, Ultra-high dose rate, Uniquely wide parameter range
Pubmed
Create date
03/01/2023 13:45
Last modification date
04/01/2023 7:50
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