FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.
Détails
ID Serval
serval:BIB_B4F1E1A64EA0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.
Périodique
Physica medica
ISSN
1724-191X (Electronic)
ISSN-L
1120-1797
Statut éditorial
Publié
Date de publication
12/2022
Peer-reviewed
Oui
Volume
104
Pages
174-187
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 10 <sup>14</sup> Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a "painting" with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.
Mots-clé
Humans, Electrons, Radiobiology, Neoplasms, FLASH and VHEE radiation therapy, Flexible electron accelerator, Online image guiding, Ultra-high dose rate, Uniquely wide parameter range
Pubmed
Création de la notice
03/01/2023 12:45
Dernière modification de la notice
04/01/2023 6:50