Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients

Détails

ID Serval
serval:BIB_B47AB7C75055
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
Périodique
Pharmacogenetics and Genomics
Auteur(s)
Crettol Séverine, Venetz Jean-Pierre, Fontana Massimiliano, Aubert John-David, Ansermot Nicolas, Fathi Marc, Pascual Manuel, Eap Chin-Bin
ISSN
1744-6872
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
307-315
Langue
anglais
Notes
SAPHIRID:68195
Résumé
OBJECTIVE: The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene, might influence cyclosporine intracellular concentration. METHODS: ABCB1 genotypes, cyclosporine intracellular and blood concentrations were determined in 64 stable renal, liver or lung transplant recipients. RESULTS: Cyclosporine intracellular concentration correlated moderately with blood concentration (r=0.30, P<0.00005). The ABCB1 1199A carriers presented a 1.8-fold decreased cyclosporine intracellular concentration (P=0.04), whereas the 3435T carriers presented a 1.7-fold increase (P=0.02) as well as a 1.2-fold increased blood concentration (P=0.04). In contrast, ABCB1 61A>G, 1236C>T and 2677G>T polymorphisms did not influence cyclosporine intracellular and blood concentrations. CONCLUSION: This is the first report demonstrating that ABCB1 polymorphisms influence cyclosporine intracellular concentration. Interestingly, its influence on intracellular concentration is significantly higher than on blood concentration (P<0.002). This may therefore modulate cyclosporine immunosuppressive activity.
Pubmed
Web of science
Création de la notice
09/06/2008 10:58
Dernière modification de la notice
20/08/2019 15:22
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