Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients

Détails

ID Serval
serval:BIB_B47AB7C75055
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
Périodique
Pharmacogenetics and Genomics
Auteur⸱e⸱s
Crettol Séverine, Venetz Jean-Pierre, Fontana Massimiliano, Aubert John-David, Ansermot Nicolas, Fathi Marc, Pascual Manuel, Eap Chin-Bin
ISSN
1744-6872
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
307-315
Langue
anglais
Notes
SAPHIRID:68195
Résumé
OBJECTIVE: The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene, might influence cyclosporine intracellular concentration. METHODS: ABCB1 genotypes, cyclosporine intracellular and blood concentrations were determined in 64 stable renal, liver or lung transplant recipients. RESULTS: Cyclosporine intracellular concentration correlated moderately with blood concentration (r=0.30, P<0.00005). The ABCB1 1199A carriers presented a 1.8-fold decreased cyclosporine intracellular concentration (P=0.04), whereas the 3435T carriers presented a 1.7-fold increase (P=0.02) as well as a 1.2-fold increased blood concentration (P=0.04). In contrast, ABCB1 61A>G, 1236C>T and 2677G>T polymorphisms did not influence cyclosporine intracellular and blood concentrations. CONCLUSION: This is the first report demonstrating that ABCB1 polymorphisms influence cyclosporine intracellular concentration. Interestingly, its influence on intracellular concentration is significantly higher than on blood concentration (P<0.002). This may therefore modulate cyclosporine immunosuppressive activity.
Pubmed
Web of science
Création de la notice
09/06/2008 10:58
Dernière modification de la notice
20/08/2019 15:22
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