Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Intensive care medicine
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Acidosis, Lactic, Adolescent, Anti-HIV Agents, Female, HIV Seropositivity, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Metabolic Clearance Rate, Pregnancy, Pregnancy Complications, Infectious, Zidovudine
Web of science
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