Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Details
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B3007614B033
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Journal
Intensive care medicine
ISSN
0342-4642
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
24
Number
3
Pages
247-50
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Keywords
Acidosis, Lactic, Adolescent, Anti-HIV Agents, Female, HIV Seropositivity, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Metabolic Clearance Rate, Pregnancy, Pregnancy Complications, Infectious, Zidovudine
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:41
Last modification date
14/02/2022 8:56
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