Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
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ID Serval
serval:BIB_B3007614B033
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Périodique
Intensive care medicine
Auteur⸱e⸱s
Scalfaro P., Chesaux J.J., Buchwalder P.A., Biollaz J., Micheli J.L.
ISSN
0342-4642
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
24
Numéro
3
Pages
247-50
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Résumé
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Mots-clé
Acidosis, Lactic, Adolescent, Anti-HIV Agents, Female, HIV Seropositivity, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Metabolic Clearance Rate, Pregnancy, Pregnancy Complications, Infectious, Zidovudine
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 10:41
Dernière modification de la notice
14/02/2022 7:56
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