Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.

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Ressource 1Download: serval:BIB_B3007614B033.P001 (321.18 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B3007614B033
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Journal
Intensive care medicine
Author(s)
Scalfaro P., Chesaux J.J., Buchwalder P.A., Biollaz J., Micheli J.L.
ISSN
0342-4642
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
24
Number
3
Pages
247-50
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Keywords
Acidosis, Lactic, Adolescent, Anti-HIV Agents, Female, HIV Seropositivity, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Metabolic Clearance Rate, Pregnancy, Pregnancy Complications, Infectious, Zidovudine
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:41
Last modification date
01/10/2019 7:19
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