Article: article from journal or magazin.
Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
Journal of Virology
The role of innate, alpha/beta interferon (IFN-alpha/beta)-dependent protection versus specific antibody-mediated protection against vesicular stomatitis virus (VSV) was evaluated in IFN-alpha/beta receptor-deficient mice (IFN-alpha/beta R0/0 mice). VSV is a close relative to rabies virus that causes neurological disease in mice. In contrast to normal mice, IFN-alpha/beta R0/0 mice were highly susceptible to infection with VSV because of ubiquitous high viral replication. Adoptive transfer experiments showed that neutralizing antibodies against the glycoprotein of VSV (VSV-G) protected these mice efficiently against systemic infection and against peripheral subcutaneous infection but protected only to a limited degree against intranasal infection with VSV. In contrast, VSV-specific T cells or antibodies specific for the nucleoprotein of VSV (VSV-N) were unable to protect IFN-alpha/beta R0/0 mice against VSV. These results demonstrate that mice are extremely sensitive to VSV if IFN-alpha/beta is not functional and that under these conditions, neutralizing antibody responses mediate efficient protection, but apparently only against extraneuronal infection.
Animals, Antibodies, Viral/immunology, Cell Line, Cercopithecus aethiops, Cricetinae, Immune Sera, Immunotherapy, Adoptive, Membrane Glycoproteins, Membrane Proteins, Mice, Neutralization Tests, Receptor, Interferon alpha-beta, Receptors, Interferon/deficiency, Rhabdoviridae Infections/immunology, Rhabdoviridae Infections/prevention &, control, Vero Cells, Vesicular stomatitis Indiana virus/immunology, Vesicular stomatitis Indiana virus/physiology, Viral Envelope Proteins/immunology, Virus Replication/physiology
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