Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.

Détails

ID Serval
serval:BIB_B2CB00B9596D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
Périodique
Journal of Virology
Auteur⸱e⸱s
Steinhoff U., Müller U., Schertler A., Hengartner H., Aguet M., Zinkernagel R.M.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
1995
Volume
69
Numéro
4
Pages
2153-2158
Langue
anglais
Résumé
The role of innate, alpha/beta interferon (IFN-alpha/beta)-dependent protection versus specific antibody-mediated protection against vesicular stomatitis virus (VSV) was evaluated in IFN-alpha/beta receptor-deficient mice (IFN-alpha/beta R0/0 mice). VSV is a close relative to rabies virus that causes neurological disease in mice. In contrast to normal mice, IFN-alpha/beta R0/0 mice were highly susceptible to infection with VSV because of ubiquitous high viral replication. Adoptive transfer experiments showed that neutralizing antibodies against the glycoprotein of VSV (VSV-G) protected these mice efficiently against systemic infection and against peripheral subcutaneous infection but protected only to a limited degree against intranasal infection with VSV. In contrast, VSV-specific T cells or antibodies specific for the nucleoprotein of VSV (VSV-N) were unable to protect IFN-alpha/beta R0/0 mice against VSV. These results demonstrate that mice are extremely sensitive to VSV if IFN-alpha/beta is not functional and that under these conditions, neutralizing antibody responses mediate efficient protection, but apparently only against extraneuronal infection.
Mots-clé
Animals, Antibodies, Viral/immunology, Cell Line, Cercopithecus aethiops, Cricetinae, Immune Sera, Immunotherapy, Adoptive, Membrane Glycoproteins, Membrane Proteins, Mice, Neutralization Tests, Receptor, Interferon alpha-beta, Receptors, Interferon/deficiency, Rhabdoviridae Infections/immunology, Rhabdoviridae Infections/prevention &amp, control, Vero Cells, Vesicular stomatitis Indiana virus/immunology, Vesicular stomatitis Indiana virus/physiology, Viral Envelope Proteins/immunology, Virus Replication/physiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:37
Dernière modification de la notice
20/08/2019 15:21
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