A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.
Details
Serval ID
serval:BIB_B1AE463C5390
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.
Journal
Molecular and cellular biology
ISSN
0270-7306
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
6
Number
12
Pages
4749-4752
Language
english
Abstract
We describe processed RNA species generated by cleavage at poly(A) sites in the immunoglobulin mu and gamma 2b heavy-chain transcription units. These "amputated transcripts" began at the first or "secreted" poly(A) site and ended at the second or "membrane" poly(A) site. Although they were polyadenylated and apparently spliced, they were largely restricted to the nucleus. Their existence confirms that the heavy-chain mRNAs are derived from RNA cleavage at alternative poly(A) sites.
Keywords
B-Lymphocytes/immunology, Base Sequence, DNA Restriction Enzymes, Genes, Humans, Immunoglobulin Heavy Chains/genetics, Poly A/genetics, RNA, Messenger/genetics, Receptors, Antigen, B-Cell/genetics, Transcription, Genetic
Pubmed
Web of science
Create date
19/11/2009 13:52
Last modification date
20/08/2019 15:20
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