A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.
Détails
ID Serval
serval:BIB_B1AE463C5390
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.
Périodique
Molecular and cellular biology
ISSN
0270-7306
Statut éditorial
Publié
Date de publication
1986
Peer-reviewed
Oui
Volume
6
Numéro
12
Pages
4749-4752
Langue
anglais
Résumé
We describe processed RNA species generated by cleavage at poly(A) sites in the immunoglobulin mu and gamma 2b heavy-chain transcription units. These "amputated transcripts" began at the first or "secreted" poly(A) site and ended at the second or "membrane" poly(A) site. Although they were polyadenylated and apparently spliced, they were largely restricted to the nucleus. Their existence confirms that the heavy-chain mRNAs are derived from RNA cleavage at alternative poly(A) sites.
Mots-clé
B-Lymphocytes/immunology, Base Sequence, DNA Restriction Enzymes, Genes, Humans, Immunoglobulin Heavy Chains/genetics, Poly A/genetics, RNA, Messenger/genetics, Receptors, Antigen, B-Cell/genetics, Transcription, Genetic
Pubmed
Web of science
Création de la notice
19/11/2009 14:52
Dernière modification de la notice
20/08/2019 16:20
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