Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Watson, H.J.; Yilmaz, Z.; Thornton, L.M.; Hübel, C.; Coleman, JRI; Gaspar, H.A.; Bryois, J.; Hinney, A.; Leppä, V.M.; Mattheisen, M.; Medland, S.E.; Ripke, S.; Yao, S.; Giusti-Rodríguez, P.; Hanscombe, K.B.; Purves, K.L.; Adan, RAH; Alfredsson, L.; Ando, T.; Andreassen, O.A.; Baker, J.H.; Berrettini, W.H.; Boehm, I.; Boni, C.; Perica, V.B.; Buehren, K.; Burghardt, R.; Cassina, M.; Cichon, S.; Clementi, M.; Cone, R.D.; Courtet, P.; Crow, S.; Crowley, J.J.; Danner, U.N.; Davis, OSP; de Zwaan, M.; Dedoussis, G.; Degortes, D.; DeSocio, J.E.; Dick, D.M.; Dikeos, D.; Dina, C.; Dmitrzak-Weglarz, M.; Docampo, E.; Duncan, L.E.; Egberts, K.; Ehrlich, S.; Escaramís, G.; Esko, T.; Estivill, X.; Farmer, A.; Favaro, A.; Fernández-Aranda, F.; Fichter, M.M.; Fischer, K.; Föcker, M.; Foretova, L.; Forstner, A.J.; Forzan, M.; Franklin, C.S.; Gallinger, S.; Giegling, I.; Giuranna, J.; Gonidakis, F.; Gorwood, P.; Mayora, M.G.; Guillaume, S.; Guo, Y.; Hakonarson, H.; Hatzikotoulas, K.; Hauser, J.; Hebebrand, J.; Helder, S.G.; Herms, S.; Herpertz-Dahlmann, B.; Herzog, W.; Huckins, L.M.; Hudson, J.I.; Imgart, H.; Inoko, H.; Janout, V.; Jiménez-Murcia, S.; Julià, A.; Kalsi, G.; Kaminská, D.; Kaprio, J.; Karhunen, L.; Karwautz, A.; Kas, MJH; Kennedy, J.L.; Keski-Rahkonen, A.; Kiezebrink, K.; Kim, Y.R.; Klareskog, L.; Klump, K.L.; Knudsen, GPS; La Via, M.C.; Le Hellard, S.; Levitan, R.D.; Li, D.; Lilenfeld, L.; Lin, B.D.; Lissowska, J.; Luykx, J.; Magistretti, P.J.; Maj, M.; Mannik, K.; Marsal, S.; Marshall, C.R.; Mattingsdal, M.; McDevitt, S.; McGuffin, P.; Metspalu, A.; Meulenbelt, I.; Micali, N.; Mitchell, K.; Monteleone, A.M.; Monteleone, P.; Munn-Chernoff, M.A.; Nacmias, B.; Navratilova, M.; Ntalla, I.; O'Toole, J.K.; Ophoff, R.A.; Padyukov, L.; Palotie, A.; Pantel, J.; Papezova, H.; Pinto, D.; Rabionet, R.; Raevuori, A.; Ramoz, N.; Reichborn-Kjennerud, T.; Ricca, V.; Ripatti, S.; Ritschel, F.; Roberts, M.; Rotondo, A.; Rujescu, D.; Rybakowski, F.; Santonastaso, P.; Scherag, A.; Scherer, S.W.; Schmidt, U.; Schork, N.J.; Schosser, A.; Seitz, J.; Slachtova, L.; Slagboom, P.E.; Slof-Op 't Landt, MCT; Slopien, A.; Sorbi, S.; Świątkowska, B.; Szatkiewicz, J.P.; Tachmazidou, I.; Tenconi, E.; Tortorella, A.; Tozzi, F.; Treasure, J.; Tsitsika, A.; Tyszkiewicz-Nwafor, M.; Tziouvas, K.; van Elburg, A.A.; van Furth, E.F.; Wagner, G.; Walton, E.; Widen, E.; Zeggini, E.; Zerwas, S.; Zipfel, S.; Bergen, A.W.; Boden, J.M.; Brandt, H.; Crawford, S.; Halmi, K.A.; Horwood, L.J.; Johnson, C.; Kaplan, A.S.; Kaye, W.H.; Mitchell, J.E.; Olsen, C.M.; Pearson, J.F.; Pedersen, N.L.; Strober, M.; Werge, T.; Whiteman, D.C.; Woodside, D.B.; Stuber, G.D.; Gordon, S.; Grove, J.; Henders, A.K.; Juréus, A.; Kirk, K.M.; Larsen, J.T.; Parker, R.; Petersen, L.; Jordan, J.; Kennedy, M.; Montgomery, G.W.; Wade, T.D.; Birgegård, A.; Lichtenstein, P.; Norring, C.; Landén, M.; Martin, N.G.; Mortensen, P.B.; Sullivan, P.F.; Breen, G.; Bulik, C.M.

doi:10.1038/s41588-019-0439-2

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

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Serval ID

serval:BIB_B13BDFAC083A

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Journal

Nature genetics

Author(s)

Watson H.J., Yilmaz Z., Thornton L.M., Hübel C., Coleman JRI, Gaspar H.A., Bryois J., Hinney A., Leppä V.M., Mattheisen M., Medland S.E., Ripke S., Yao S., Giusti-Rodríguez P., Hanscombe K.B., Purves K.L., Adan RAH, Alfredsson L., Ando T., Andreassen O.A., Baker J.H., Berrettini W.H., Boehm I., Boni C., Perica V.B., Buehren K., Burghardt R., Cassina M., Cichon S., Clementi M., Cone R.D., Courtet P., Crow S., Crowley J.J., Danner U.N., Davis OSP, de Zwaan M., Dedoussis G., Degortes D., DeSocio J.E., Dick D.M., Dikeos D., Dina C., Dmitrzak-Weglarz M., Docampo E., Duncan L.E., Egberts K., Ehrlich S., Escaramís G., Esko T., Estivill X., Farmer A., Favaro A., Fernández-Aranda F., Fichter M.M., Fischer K., Föcker M., Foretova L., Forstner A.J., Forzan M., Franklin C.S., Gallinger S., Giegling I., Giuranna J., Gonidakis F., Gorwood P., Mayora M.G., Guillaume S., Guo Y., Hakonarson H., Hatzikotoulas K., Hauser J., Hebebrand J., Helder S.G., Herms S., Herpertz-Dahlmann B., Herzog W., Huckins L.M., Hudson J.I., Imgart H., Inoko H., Janout V., Jiménez-Murcia S., Julià A., Kalsi G., Kaminská D., Kaprio J., Karhunen L., Karwautz A., Kas MJH, Kennedy J.L., Keski-Rahkonen A., Kiezebrink K., Kim Y.R., Klareskog L., Klump K.L., Knudsen GPS, La Via M.C., Le Hellard S., Levitan R.D., Li D., Lilenfeld L., Lin B.D., Lissowska J., Luykx J., Magistretti P.J., Maj M., Mannik K., Marsal S., Marshall C.R., Mattingsdal M., McDevitt S., McGuffin P., Metspalu A., Meulenbelt I., Micali N., Mitchell K., Monteleone A.M., Monteleone P., Munn-Chernoff M.A., Nacmias B., Navratilova M., Ntalla I., O'Toole J.K., Ophoff R.A., Padyukov L., Palotie A., Pantel J., Papezova H., Pinto D., Rabionet R., Raevuori A., Ramoz N., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rotondo A., Rujescu D., Rybakowski F., Santonastaso P., Scherag A., Scherer S.W., Schmidt U., Schork N.J., Schosser A., Seitz J., Slachtova L., Slagboom P.E., Slof-Op 't Landt MCT, Slopien A., Sorbi S., Świątkowska B., Szatkiewicz J.P., Tachmazidou I., Tenconi E., Tortorella A., Tozzi F., Treasure J., Tsitsika A., Tyszkiewicz-Nwafor M., Tziouvas K., van Elburg A.A., van Furth E.F., Wagner G., Walton E., Widen E., Zeggini E., Zerwas S., Zipfel S., Bergen A.W., Boden J.M., Brandt H., Crawford S., Halmi K.A., Horwood L.J., Johnson C., Kaplan A.S., Kaye W.H., Mitchell J.E., Olsen C.M., Pearson J.F., Pedersen N.L., Strober M., Werge T., Whiteman D.C., Woodside D.B., Stuber G.D., Gordon S., Grove J., Henders A.K., Juréus A., Kirk K.M., Larsen J.T., Parker R., Petersen L., Jordan J., Kennedy M., Montgomery G.W., Wade T.D., Birgegård A., Lichtenstein P., Norring C., Landén M., Martin N.G., Mortensen P.B., Sullivan P.F., Breen G., Bulik C.M.

Working group(s)

Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

08/2019

Peer-reviewed

Oui

Volume

Number

Pages

1207-1214

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness 1 , affecting 0.9-4% of women and 0.3% of men 2-4 , with twin-based heritability estimates of 50-60% 5 . Mortality rates are higher than those in other psychiatric disorders 6 , and outcomes are unacceptably poor 7 . Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI) 8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Keywords

Adult, Anorexia Nervosa/etiology, Anorexia Nervosa/genetics, Anorexia Nervosa/pathology, Body Mass Index, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics/methods, Humans, Male, Mental Disorders/complications, Mental Disorders/genetics, Metabolic Diseases/complications, Metabolic Diseases/genetics, Phenotype, Prognosis, Quantitative Trait Loci

OAI-PMH

oai:serval.unil.ch:BIB_B13BDFAC083A

DOI

10.1038/s41588-019-0439-2

Pubmed

31308545

Web of science

000477946700007

Create date

22/07/2019 17:07

Last modification date

30/01/2020 7:20

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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Details