Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

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ID Serval
serval:BIB_B13BDFAC083A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Périodique
Nature genetics
Auteur⸱e⸱s
Watson H.J., Yilmaz Z., Thornton L.M., Hübel C., Coleman JRI, Gaspar H.A., Bryois J., Hinney A., Leppä V.M., Mattheisen M., Medland S.E., Ripke S., Yao S., Giusti-Rodríguez P., Hanscombe K.B., Purves K.L., Adan RAH, Alfredsson L., Ando T., Andreassen O.A., Baker J.H., Berrettini W.H., Boehm I., Boni C., Perica V.B., Buehren K., Burghardt R., Cassina M., Cichon S., Clementi M., Cone R.D., Courtet P., Crow S., Crowley J.J., Danner U.N., Davis OSP, de Zwaan M., Dedoussis G., Degortes D., DeSocio J.E., Dick D.M., Dikeos D., Dina C., Dmitrzak-Weglarz M., Docampo E., Duncan L.E., Egberts K., Ehrlich S., Escaramís G., Esko T., Estivill X., Farmer A., Favaro A., Fernández-Aranda F., Fichter M.M., Fischer K., Föcker M., Foretova L., Forstner A.J., Forzan M., Franklin C.S., Gallinger S., Giegling I., Giuranna J., Gonidakis F., Gorwood P., Mayora M.G., Guillaume S., Guo Y., Hakonarson H., Hatzikotoulas K., Hauser J., Hebebrand J., Helder S.G., Herms S., Herpertz-Dahlmann B., Herzog W., Huckins L.M., Hudson J.I., Imgart H., Inoko H., Janout V., Jiménez-Murcia S., Julià A., Kalsi G., Kaminská D., Kaprio J., Karhunen L., Karwautz A., Kas MJH, Kennedy J.L., Keski-Rahkonen A., Kiezebrink K., Kim Y.R., Klareskog L., Klump K.L., Knudsen GPS, La Via M.C., Le Hellard S., Levitan R.D., Li D., Lilenfeld L., Lin B.D., Lissowska J., Luykx J., Magistretti P.J., Maj M., Mannik K., Marsal S., Marshall C.R., Mattingsdal M., McDevitt S., McGuffin P., Metspalu A., Meulenbelt I., Micali N., Mitchell K., Monteleone A.M., Monteleone P., Munn-Chernoff M.A., Nacmias B., Navratilova M., Ntalla I., O'Toole J.K., Ophoff R.A., Padyukov L., Palotie A., Pantel J., Papezova H., Pinto D., Rabionet R., Raevuori A., Ramoz N., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rotondo A., Rujescu D., Rybakowski F., Santonastaso P., Scherag A., Scherer S.W., Schmidt U., Schork N.J., Schosser A., Seitz J., Slachtova L., Slagboom P.E., Slof-Op 't Landt MCT, Slopien A., Sorbi S., Świątkowska B., Szatkiewicz J.P., Tachmazidou I., Tenconi E., Tortorella A., Tozzi F., Treasure J., Tsitsika A., Tyszkiewicz-Nwafor M., Tziouvas K., van Elburg A.A., van Furth E.F., Wagner G., Walton E., Widen E., Zeggini E., Zerwas S., Zipfel S., Bergen A.W., Boden J.M., Brandt H., Crawford S., Halmi K.A., Horwood L.J., Johnson C., Kaplan A.S., Kaye W.H., Mitchell J.E., Olsen C.M., Pearson J.F., Pedersen N.L., Strober M., Werge T., Whiteman D.C., Woodside D.B., Stuber G.D., Gordon S., Grove J., Henders A.K., Juréus A., Kirk K.M., Larsen J.T., Parker R., Petersen L., Jordan J., Kennedy M., Montgomery G.W., Wade T.D., Birgegård A., Lichtenstein P., Norring C., Landén M., Martin N.G., Mortensen P.B., Sullivan P.F., Breen G., Bulik C.M.
Collaborateur⸱rice⸱s
Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
08/2019
Peer-reviewed
Oui
Volume
51
Numéro
8
Pages
1207-1214
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness <sup>1</sup> , affecting 0.9-4% of women and 0.3% of men <sup>2-4</sup> , with twin-based heritability estimates of 50-60% <sup>5</sup> . Mortality rates are higher than those in other psychiatric disorders <sup>6</sup> , and outcomes are unacceptably poor <sup>7</sup> . Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI) <sup>8,9</sup> and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
Mots-clé
Adult, Anorexia Nervosa/etiology, Anorexia Nervosa/genetics, Anorexia Nervosa/pathology, Body Mass Index, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics/methods, Humans, Male, Mental Disorders/complications, Mental Disorders/genetics, Metabolic Diseases/complications, Metabolic Diseases/genetics, Phenotype, Prognosis, Quantitative Trait Loci
OAI-PMH
oai:serval.unil.ch:BIB_B13BDFAC083A
DOI
10.1038/s41588-019-0439-2
Pubmed
31308545
Web of science
000477946700007
Création de la notice
22/07/2019 17:07
Dernière modification de la notice
30/01/2020 7:20
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