Going the distance: human population genetics in a clinal world.

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serval:BIB_B0CA510362E4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Going the distance: human population genetics in a clinal world.
Journal
Trends in Genetics
Author(s)
Handley L.J., Manica A., Goudet J., Balloux F.
ISSN
0168-9525[print], 0168-9525[linking]
Publication state
Published
Issued date
2007
Volume
23
Number
9
Pages
432-439
Language
english
Abstract
Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics.
Keywords
Emigration and Immigration, Genetic Variation, Genetics, Population, Geography, Humans, Models, Biological, Models, Genetic, Selection, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 17:10
Last modification date
20/08/2019 15:19
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