Mouse mammary tumor virus superantigens and murine autoimmune gastritis.

Details

Serval ID
serval:BIB_AE5D749B4C65
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mouse mammary tumor virus superantigens and murine autoimmune gastritis.
Journal
Gastroenterology
Author(s)
Claeys D., Karapetian O., Saraga E., Schreyer M., Louis J., Acha-Orbea H., Blum A.L., Kraehenbuhl J.P.
ISSN
0016-5085 (Print)
ISSN-L
0016-5085
Publication state
Published
Issued date
1994
Volume
107
Number
4
Pages
924-933
Language
english
Abstract
BACKGROUND/AIMS: Neonatal thymectomy induces autoimmune gastritis in BALB/c (minor lymphocyte-stimulating antigen [Mls]-1b) mice, whereas DBA/2 (Mls-1a) mice are resistant. Resistance has been linked to the Mls-1a locus, which encodes a retroviral superantigen, and to superantigen reactive T cells that express V beta 6+ T-cell receptors. V beta 6+ T cells are known to be deleted in mice expressing Mls-1a superantigens. METHODS: Neonatal thymectomized BALB/c and Mls-1a congenic BALB.D2.Mls-1a mice were analyzed to examine directly the role of Mls-1a self-superantigens and V beta 6+ T cells in autoimmune gastritis. RESULTS: Autoimmune gastritis was detected in thymectomized BALB.D2.Mls-1a mice with high incidence. Autoantibodies to the gastric H+,K(+)-adenosine triphosphatase were present independent of the Mls phenotype in sera of gastritic mice. Severe gastritis had already appeared 1 month after thymectomy in BALB.D2.Mls-1a mice. V beta 6+ T cells were deleted in the stomach lymph nodes of 1-month-old gastritic BALB.D2.Mls-1a mice but could be detected by immunocytochemistry in the stomach lesions. CONCLUSIONS: Endogenous Mls-1a self-superantigens and Mls-1a reactive V beta 6+ T cells are not involved in resistance to autoimmune gastritis in BALB.D2 mice.
Keywords
Animals, Animals, Newborn, Autoimmune Diseases/immunology, CD4-Positive T-Lymphocytes/metabolism, CD4-Positive T-Lymphocytes/physiology, Disease Susceptibility, Gastritis/immunology, Gastritis/pathology, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Receptors, Antigen, T-Cell/metabolism, Superantigens/immunology, Thymectomy
Pubmed
Web of science
Create date
24/01/2008 15:48
Last modification date
20/08/2019 16:18
Usage data