Mouse mammary tumor virus superantigens and murine autoimmune gastritis.

Détails

ID Serval
serval:BIB_AE5D749B4C65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mouse mammary tumor virus superantigens and murine autoimmune gastritis.
Périodique
Gastroenterology
Auteur⸱e⸱s
Claeys D., Karapetian O., Saraga E., Schreyer M., Louis J., Acha-Orbea H., Blum A.L., Kraehenbuhl J.P.
ISSN
0016-5085 (Print)
ISSN-L
0016-5085
Statut éditorial
Publié
Date de publication
1994
Volume
107
Numéro
4
Pages
924-933
Langue
anglais
Résumé
BACKGROUND/AIMS: Neonatal thymectomy induces autoimmune gastritis in BALB/c (minor lymphocyte-stimulating antigen [Mls]-1b) mice, whereas DBA/2 (Mls-1a) mice are resistant. Resistance has been linked to the Mls-1a locus, which encodes a retroviral superantigen, and to superantigen reactive T cells that express V beta 6+ T-cell receptors. V beta 6+ T cells are known to be deleted in mice expressing Mls-1a superantigens. METHODS: Neonatal thymectomized BALB/c and Mls-1a congenic BALB.D2.Mls-1a mice were analyzed to examine directly the role of Mls-1a self-superantigens and V beta 6+ T cells in autoimmune gastritis. RESULTS: Autoimmune gastritis was detected in thymectomized BALB.D2.Mls-1a mice with high incidence. Autoantibodies to the gastric H+,K(+)-adenosine triphosphatase were present independent of the Mls phenotype in sera of gastritic mice. Severe gastritis had already appeared 1 month after thymectomy in BALB.D2.Mls-1a mice. V beta 6+ T cells were deleted in the stomach lymph nodes of 1-month-old gastritic BALB.D2.Mls-1a mice but could be detected by immunocytochemistry in the stomach lesions. CONCLUSIONS: Endogenous Mls-1a self-superantigens and Mls-1a reactive V beta 6+ T cells are not involved in resistance to autoimmune gastritis in BALB.D2 mice.
Mots-clé
Animals, Animals, Newborn, Autoimmune Diseases/immunology, CD4-Positive T-Lymphocytes/metabolism, CD4-Positive T-Lymphocytes/physiology, Disease Susceptibility, Gastritis/immunology, Gastritis/pathology, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Receptors, Antigen, T-Cell/metabolism, Superantigens/immunology, Thymectomy
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 16:18
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