Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Details
Serval ID
serval:BIB_AC57CA72EBF5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Journal
Haematologica
ISSN
1592-8721 (Electronic)
ISSN-L
0390-6078
Publication state
Published
Issued date
05/2005
Peer-reviewed
Oui
Volume
90
Number
5
Pages
691-693
Language
english
Notes
Publication types: Letter ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders. Long-term treatment with azathioprine seems to be associated with an increased risk of MDS and subsequent leukemic transformation.
Keywords
Adult, Aged, Aged, 80 and over, Autoimmune Diseases/drug therapy, Azathioprine/adverse effects, Azathioprine/therapeutic use, Cell Transformation, Neoplastic/chemically induced, Chromosomes, Human, Pair 7/ultrastructure, Female, Heart Transplantation, Humans, Immunosuppressive Agents/adverse effects, Immunosuppressive Agents/therapeutic use, In Situ Hybridization, Fluorescence, Kidney Transplantation, Male, Middle Aged, Monosomy, Myelodysplastic Syndromes/chemically induced, Myelodysplastic Syndromes/genetics, Postoperative Complications/chemically induced, Retrospective Studies, Rheumatic Diseases/drug therapy, Translocation, Genetic
Pubmed
Web of science
Create date
16/07/2019 13:37
Last modification date
21/08/2019 6:37
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