Nouvelle lumière sur la thérapie photodynamique cutanée [New light on skin photodynamic therapy]

Details

Serval ID
serval:BIB_AB83BF8E543D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Nouvelle lumière sur la thérapie photodynamique cutanée [New light on skin photodynamic therapy]
Journal
Revue medicale suisse
Author(s)
Kuonen F., Gaide O.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
02/04/2014
Volume
10
Number
424
Pages
754,756-759
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Photodynamic therapy (PDT) relies on the cellular toxicity of an exogenous porphyrin that is activated by light rays. Its specificity depends on its cellular uptake, which is typically high in cells with a high metabolism, such as cancer cells and several microbial pathogens. Both the diffusion of the substrate and the penetration of the light in the tissue limit its efficiency to the first few millimeters of the skin. This explains why this technique is used for the treatment of superficial skin cancers (actinic keratosis and basal cell carcinomas), but also for selected skin inflammatory diseases (psoriasis) or infections (leishmaniosis). However, at the bedside, the limitations of PDT are rather the complexity and the pain associated with the treatment. Herein, we present the new developments, in particular concerning the new light sources, which make PDT a better option for our patients.

Keywords
Humans, Light, Photochemotherapy/adverse effects, Photochemotherapy/trends, Photochemotherapy/utilization, Professional Practice/standards, Protoporphyrins/administration & dosage, Skin Diseases/drug therapy
Pubmed
Create date
02/11/2017 12:05
Last modification date
20/08/2019 15:15
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