Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer
Therapeutic drug monitoring
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
A very long half-life of paroxetine (195 h instead of the usual value of around 16 h) was measured after an overdose with 2 g paroxetine and 1 g clorazepate in a patient who was an extensive cytochrome P4502D6 metabolizer. The patient recovered well without any clinically significant complications. A consequence of the close monitoring of paroxetine levels in this patient was that it was decided not to reintroduce any other antidepressant despite her suicide attempt, until normal levels of paroxetine had been reached, which took over 1 month.
Anti-Anxiety Agents, Antidepressive Agents, Second-Generation, Anxiety, Clorazepate Dipotassium, Cytochrome P-450 CYP2D6, Depressive Disorder, Drug Interactions, Female, Half-Life, Humans, Middle Aged, Overdose, Paroxetine, Suicide, Attempted
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