Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer

Détails

ID Serval
serval:BIB_A9FB304D3F98
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer
Périodique
Therapeutic drug monitoring
Auteur⸱e⸱s
Hilleret H., Voirol P., Bovier P., Giannakopoulos P., Zullino D., Baumann P., Giroud C., Rivier L., Eap C.B.
ISSN
0163-4356
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
24
Numéro
4
Pages
567-569
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Résumé
A very long half-life of paroxetine (195 h instead of the usual value of around 16 h) was measured after an overdose with 2 g paroxetine and 1 g clorazepate in a patient who was an extensive cytochrome P4502D6 metabolizer. The patient recovered well without any clinically significant complications. A consequence of the close monitoring of paroxetine levels in this patient was that it was decided not to reintroduce any other antidepressant despite her suicide attempt, until normal levels of paroxetine had been reached, which took over 1 month.
Mots-clé
Anti-Anxiety Agents, Antidepressive Agents, Second-Generation, Anxiety, Clorazepate Dipotassium, Cytochrome P-450 CYP2D6, Depressive Disorder, Drug Interactions, Female, Half-Life, Humans, Middle Aged, Overdose, Paroxetine, Suicide, Attempted
Pubmed
Web of science
Création de la notice
10/03/2008 10:53
Dernière modification de la notice
20/08/2019 15:14
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