Prospective determination of imipenem concentration of the plasma of critically-ill children
Details
State: Public
Version: After imprimatur
Serval ID
serval:BIB_A9F833DEAECB
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Prospective determination of imipenem concentration of the plasma of critically-ill children
Director(s)
Moreillon P.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Address
Lausanne
Publication state
Accepted
Issued date
2006
Language
english
Number of pages
21
Notes
REROID:R004198273; autres auteurs: Cotting J., Moessinger A., Bille J., Décosterd L.A., Zanetti G., Majcherczyk P., Bugnon D.
Abstract
ABSTRACT
Imipenem plasma-concentrations were measured in 19 critically-ill children (median 0.8 year, range 0.02-12.9 years). Wide inter-individual variations (2-4x at peak and >10x at through concentrations) resulted in unpredictable plasma-levels in several children. To avoid subtherapeutic drug levels we recommend at least 100 mg/kg/day of imipenem-cilastatin in critically-ill children requiring such therapy.
Imipenem plasma-concentrations were measured in 19 critically-ill children (median 0.8 year, range 0.02-12.9 years). Wide inter-individual variations (2-4x at peak and >10x at through concentrations) resulted in unpredictable plasma-levels in several children. To avoid subtherapeutic drug levels we recommend at least 100 mg/kg/day of imipenem-cilastatin in critically-ill children requiring such therapy.
Keywords
Monitoring, Pharmacokinetics, plasma concentration, imipenem-cilastatin, intensive care unit, children
Create date
15/10/2010 13:37
Last modification date
20/08/2019 16:14
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