Prospective determination of imipenem concentration of the plasma of critically-ill children
Détails
Etat: Public
Version: Après imprimatur
ID Serval
serval:BIB_A9F833DEAECB
Type
Thèse: thèse de doctorat.
Collection
Publications
Institution
Titre
Prospective determination of imipenem concentration of the plasma of critically-ill children
Directeur⸱rice⸱s
Moreillon P.
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Adresse
Lausanne
Statut éditorial
Acceptée
Date de publication
2006
Langue
anglais
Nombre de pages
21
Notes
REROID:R004198273; autres auteurs: Cotting J., Moessinger A., Bille J., Décosterd L.A., Zanetti G., Majcherczyk P., Bugnon D.
Résumé
ABSTRACT
Imipenem plasma-concentrations were measured in 19 critically-ill children (median 0.8 year, range 0.02-12.9 years). Wide inter-individual variations (2-4x at peak and >10x at through concentrations) resulted in unpredictable plasma-levels in several children. To avoid subtherapeutic drug levels we recommend at least 100 mg/kg/day of imipenem-cilastatin in critically-ill children requiring such therapy.
Imipenem plasma-concentrations were measured in 19 critically-ill children (median 0.8 year, range 0.02-12.9 years). Wide inter-individual variations (2-4x at peak and >10x at through concentrations) resulted in unpredictable plasma-levels in several children. To avoid subtherapeutic drug levels we recommend at least 100 mg/kg/day of imipenem-cilastatin in critically-ill children requiring such therapy.
Mots-clé
Monitoring, Pharmacokinetics, plasma concentration, imipenem-cilastatin, intensive care unit, children
Création de la notice
15/10/2010 12:37
Dernière modification de la notice
20/08/2019 15:14
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