Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.
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Serval ID
serval:BIB_A986016791AB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.
Journal
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
2013
Volume
38
Number
5
Pages
1013-1024
Language
english
Abstract
The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs. Although T cell zone reticular cells had lost podoplanin expression, they still formed a functional conduit system and showed enhanced expression of myofibroblastic markers. However, essential immune functions of FRCs, including homeostatic chemokine and interleukin-7 expression, were impaired. These changes in T cell zone reticular cell function were associated with increased susceptibility to viral infection. Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
Keywords
Animals, Cell Differentiation, Cells, Cultured, Coronavirus Infections/immunology, Fibroblasts/cytology, Fibroblasts/immunology, Interleukin-7/biosynthesis, Lymph Nodes/cytology, Lymph Nodes/immunology, Lymphotoxin beta Receptor/metabolism, Lymphotoxin-beta/biosynthesis, Lymphotoxin-beta/metabolism, Membrane Glycoproteins/biosynthesis, Mesenchymal Stromal Cells/metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Murine hepatitis virus/immunology, Myofibroblasts/cytology, Myofibroblasts/physiology, Signal Transduction, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2014 14:43
Last modification date
25/01/2024 7:42