Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

Détails

ID Serval
serval:BIB_A986016791AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.
Périodique
Immunity
Auteur⸱e⸱s
Chai Q., Onder L., Scandella E., Gil-Cruz C., Perez-Shibayama C., Cupovic J., Danuser R., Sparwasser T., Luther S.A., Thiel V., Rülicke T., Stein J.V., Hehlgans T., Ludewig B.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
2013
Volume
38
Numéro
5
Pages
1013-1024
Langue
anglais
Résumé
The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs. Although T cell zone reticular cells had lost podoplanin expression, they still formed a functional conduit system and showed enhanced expression of myofibroblastic markers. However, essential immune functions of FRCs, including homeostatic chemokine and interleukin-7 expression, were impaired. These changes in T cell zone reticular cell function were associated with increased susceptibility to viral infection. Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
Mots-clé
Animals, Cell Differentiation, Cells, Cultured, Coronavirus Infections/immunology, Fibroblasts/cytology, Fibroblasts/immunology, Interleukin-7/biosynthesis, Lymph Nodes/cytology, Lymph Nodes/immunology, Lymphotoxin beta Receptor/metabolism, Lymphotoxin-beta/biosynthesis, Lymphotoxin-beta/metabolism, Membrane Glycoproteins/biosynthesis, Mesenchymal Stromal Cells/metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Murine hepatitis virus/immunology, Myofibroblasts/cytology, Myofibroblasts/physiology, Signal Transduction, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/01/2014 15:43
Dernière modification de la notice
20/08/2019 16:13
Données d'usage