Article: article from journal or magazin.
Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin
Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb 21
A central feature of host defence is the ability of leukocytes to enter tissues in response to immune or inflammatory stimuli. The leukocyte adhesion molecule-1 (LAM-1) regulates the migration of human leukocytes by mediating the binding both of lymphocytes to high endothelial venules of peripheral lymph nodes and of neutrophils to endothelium at inflammatory sites. As lymphocytes and neutrophils express the same LAM-1 protein, it is not clear how lineage-specific differences in leukocyte migration are controlled. We now report that the affinity of LAM-1 for a carbohydrate-based ligand, PPME, is dramatically increased following lymphocyte and neutrophil activation by lineage-specific stimuli. In addition, activation of lymphocytes by physiological stimuli enhanced LAM-1-dependent binding to high endothelial venules. Thus, transient changes in LAM-1 affinity after leukocyte stimulation probably directly influence leukocyte migration.
Antibodies, Monoclonal/diagnostic use Antigens, CD2 Antigens, Differentiation, T-Lymphocyte Cell Adhesion/drug effects/physiology Cell Adhesion Molecules/*metabolism Cell Movement/physiology Cross-Linking Reagents Edetic Acid/pharmacology Endothelium, Vascular/metabolism Granulocyte Colony-Stimulating Factor/physiology Granulocyte-Macrophage Colony-Stimulating Factor/physiology Humans L-Selectin Lymphocyte Activation Lymphocytes/drug effects/*metabolism Mannans/*metabolism Mannosephosphates/*metabolism Neutrophils/drug effects/*metabolism Receptors, Immunologic T-Lymphocytes/metabolism
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