Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin

Détails

ID Serval
serval:BIB_A971D4751854
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin
Périodique
Nature
Auteur⸱e⸱s
Spertini  O., Kansas  G. S., Munro  J. M., Griffin  J. D., Tedder  T. F.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
02/1991
Volume
349
Numéro
6311
Pages
691-694
Langue
anglais
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb 21
Résumé
A central feature of host defence is the ability of leukocytes to enter tissues in response to immune or inflammatory stimuli. The leukocyte adhesion molecule-1 (LAM-1) regulates the migration of human leukocytes by mediating the binding both of lymphocytes to high endothelial venules of peripheral lymph nodes and of neutrophils to endothelium at inflammatory sites. As lymphocytes and neutrophils express the same LAM-1 protein, it is not clear how lineage-specific differences in leukocyte migration are controlled. We now report that the affinity of LAM-1 for a carbohydrate-based ligand, PPME, is dramatically increased following lymphocyte and neutrophil activation by lineage-specific stimuli. In addition, activation of lymphocytes by physiological stimuli enhanced LAM-1-dependent binding to high endothelial venules. Thus, transient changes in LAM-1 affinity after leukocyte stimulation probably directly influence leukocyte migration.
Mots-clé
Antibodies, Monoclonal/diagnostic use Antigens, CD2 Antigens, Differentiation, T-Lymphocyte Cell Adhesion/drug effects/physiology Cell Adhesion Molecules/*metabolism Cell Movement/physiology Cross-Linking Reagents Edetic Acid/pharmacology Endothelium, Vascular/metabolism Granulocyte Colony-Stimulating Factor/physiology Granulocyte-Macrophage Colony-Stimulating Factor/physiology Humans L-Selectin Lymphocyte Activation Lymphocytes/drug effects/*metabolism Mannans/*metabolism Mannosephosphates/*metabolism Neutrophils/drug effects/*metabolism Receptors, Immunologic T-Lymphocytes/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 16:31
Dernière modification de la notice
20/08/2019 16:13
Données d'usage