Serological abnormalities induced by engraftment of viable motheaten hematopoietic cells in nude beige recipients
Details
Serval ID
serval:BIB_A925CD500463
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serological abnormalities induced by engraftment of viable motheaten hematopoietic cells in nude beige recipients
Journal
Autoimmunity
ISSN
0891-6934 (Print)
Publication state
Published
Issued date
1995
Volume
20
Number
1
Pages
25-32
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Abstract
C57BL/6J (B6) mice homozygous for the viable motheaten (mev) mutation are short-lived and display severe immunodeficiency, autoimmunity and inflammatory disease. B6 mice doubly homozygous for the nude (nu) and beige (bg) mutations (nubg mice) are also short-lived and immunodeficient. Nevertheless, grafts of mev lympho-hematopoietic cells increased life expectancy of nubg recipients. Such [mev --> nubg] chimeras did not develop any mev-like inflammatory pathology but showed autoimmunity features, particularly hyperglobulinemia which, unlike the mev one, was due to IgG rather than IgM. Serological studies of [mev IgHb --> nubg Igha] chimeras surprisingly revealed the exclusive host B-cell origin of the IgG2a overproduced by these chimeras. Yet, about half of such chimera serum IgM being IgMb, mev B cells had actually engrafted the nubg hosts. Together with the lack of transfer of the inflammatory pathology, this suggests that a non-mev environment might succeed acting as a regulator of some mev-induced dysfunctions.
Keywords
Animals
Antibodies, Antinuclear/blood
Antibody Specificity/genetics
B-Lymphocytes/metabolism
DNA, Single-Stranded/immunology
Female
Genes, Recessive/*immunology
*Hematopoietic Stem Cell Transplantation
Immunoglobulin G/biosynthesis
Immunoglobulin Isotypes/*blood/genetics
Immunoglobulin M/biosynthesis
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Nude
Radiation Chimera
Pubmed
Web of science
Create date
25/01/2008 16:10
Last modification date
20/08/2019 15:13