Serological abnormalities induced by engraftment of viable motheaten hematopoietic cells in nude beige recipients

Détails

ID Serval
serval:BIB_A925CD500463
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Serological abnormalities induced by engraftment of viable motheaten hematopoietic cells in nude beige recipients
Périodique
Autoimmunity
Auteur⸱e⸱s
Velin  D., Kuntz  L., Loor  F.
ISSN
0891-6934 (Print)
Statut éditorial
Publié
Date de publication
1995
Volume
20
Numéro
1
Pages
25-32
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
C57BL/6J (B6) mice homozygous for the viable motheaten (mev) mutation are short-lived and display severe immunodeficiency, autoimmunity and inflammatory disease. B6 mice doubly homozygous for the nude (nu) and beige (bg) mutations (nubg mice) are also short-lived and immunodeficient. Nevertheless, grafts of mev lympho-hematopoietic cells increased life expectancy of nubg recipients. Such [mev --> nubg] chimeras did not develop any mev-like inflammatory pathology but showed autoimmunity features, particularly hyperglobulinemia which, unlike the mev one, was due to IgG rather than IgM. Serological studies of [mev IgHb --> nubg Igha] chimeras surprisingly revealed the exclusive host B-cell origin of the IgG2a overproduced by these chimeras. Yet, about half of such chimera serum IgM being IgMb, mev B cells had actually engrafted the nubg hosts. Together with the lack of transfer of the inflammatory pathology, this suggests that a non-mev environment might succeed acting as a regulator of some mev-induced dysfunctions.
Mots-clé
Animals Antibodies, Antinuclear/blood Antibody Specificity/genetics B-Lymphocytes/metabolism DNA, Single-Stranded/immunology Female Genes, Recessive/*immunology *Hematopoietic Stem Cell Transplantation Immunoglobulin G/biosynthesis Immunoglobulin Isotypes/*blood/genetics Immunoglobulin M/biosynthesis Male Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Nude Radiation Chimera
Pubmed
Web of science
Création de la notice
25/01/2008 16:10
Dernière modification de la notice
20/08/2019 15:13
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