Homeostasis Meets Motivation in the Battle to Control Food Intake.

Détails

Ressource 1Télécharger: 11469.full.pdf (443.78 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_A6A37D5B2C94
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Homeostasis Meets Motivation in the Battle to Control Food Intake.
Périodique
The Journal of neuroscience
Auteur(s)
Ferrario C.R., Labouèbe G., Liu S., Nieh E.H., Routh V.H., Xu S., O'Connor E.C.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
09/11/2016
Peer-reviewed
Oui
Volume
36
Numéro
45
Pages
11469-11481
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Signals of energy homeostasis interact closely with neural circuits of motivation to control food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior seen in eating disorders or obesity may arise from dysregulation of these interactions. Focusing on key brain regions involved in the control of food intake (ventral tegmental area, striatum, hypothalamus, and thalamus), we describe how activity of specific cell types embedded within these regions can influence distinct components of motivated feeding behavior. We review how signals of energy homeostasis interact with these regions to influence motivated behavioral output and present evidence that experience-dependent neural adaptations in key feeding circuits may represent cellular correlates of impaired food intake control. Future research into mechanisms that restore the balance of control between signals of homeostasis and motivated feeding behavior may inspire new treatment options for eating disorders and obesity.

Mots-clé
Animals, Appetite Regulation/physiology, Body Weight/physiology, Brain/physiology, Eating/physiology, Energy Metabolism/physiology, Homeostasis/physiology, Humans, Motivation/physiology, AGRP, POMC, accumbens, arculate nucleus, dieting, dopamine, ghrelin, glucose, insulin, leptin, orexin, paraventricular thalamic nucleus, reward
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/12/2016 19:59
Dernière modification de la notice
20/08/2019 15:11
Données d'usage