Mécanismes pathogéniques de la sclérodermie et leurs conséquences thérapeutiques. 1ère partie: pathogénie [Pathogenic mechanisms in systemic sclerosis and their therapeutical consequences. Part 1: pathogenesis]

Details

Serval ID
serval:BIB_A3A4A5BDE446
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mécanismes pathogéniques de la sclérodermie et leurs conséquences thérapeutiques. 1ère partie: pathogénie [Pathogenic mechanisms in systemic sclerosis and their therapeutical consequences. Part 1: pathogenesis]
Journal
Revue Médicale Suisse
Author(s)
Zuber J. P., Chizzolini C., Leimgruber A., Bart P. A., Spertini F.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
2006
Volume
2
Number
62
Pages
1052-7
Notes
English Abstract Journal Article Review
Abstract
Systemic sclerosis I(cleroderma) is a connective tissue disease caracterized by an aberrant immune activation, a vasculopathy and a fibrosis of skin and multiple internal organs (lung, kidneys, gut, among others). At present no unifying pathogenetic hypothesis exists to explain all aspects of this disease. The current hypothesis is that in patients with a favourable genetic background, certain environmental factors could produce alterations of cellular and humoral immunity and alterations of the microcirculation resulting in excessive fibrosis. A crucial component in systemic sclerosis pathogenesis is the persistent and unregulated activation of genes encoding the various extracellular matrix proteins. This is in correlation with different cytokines and growth factors produced mainly by T lymphocytes.
Keywords
Fibrosis/complications Humans Scleroderma, Systemic/*etiology/immunology Vascular Diseases/complications
Pubmed
Create date
25/01/2008 15:19
Last modification date
20/08/2019 15:09
Usage data