Mécanismes pathogéniques de la sclérodermie et leurs conséquences thérapeutiques. 1ère partie: pathogénie [Pathogenic mechanisms in systemic sclerosis and their therapeutical consequences. Part 1: pathogenesis]

Détails

ID Serval
serval:BIB_A3A4A5BDE446
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mécanismes pathogéniques de la sclérodermie et leurs conséquences thérapeutiques. 1ère partie: pathogénie [Pathogenic mechanisms in systemic sclerosis and their therapeutical consequences. Part 1: pathogenesis]
Périodique
Revue Médicale Suisse
Auteur⸱e⸱s
Zuber J. P., Chizzolini C., Leimgruber A., Bart P. A., Spertini F.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
2
Numéro
62
Pages
1052-7
Notes
English Abstract Journal Article Review
Résumé
Systemic sclerosis I(cleroderma) is a connective tissue disease caracterized by an aberrant immune activation, a vasculopathy and a fibrosis of skin and multiple internal organs (lung, kidneys, gut, among others). At present no unifying pathogenetic hypothesis exists to explain all aspects of this disease. The current hypothesis is that in patients with a favourable genetic background, certain environmental factors could produce alterations of cellular and humoral immunity and alterations of the microcirculation resulting in excessive fibrosis. A crucial component in systemic sclerosis pathogenesis is the persistent and unregulated activation of genes encoding the various extracellular matrix proteins. This is in correlation with different cytokines and growth factors produced mainly by T lymphocytes.
Mots-clé
Fibrosis/complications Humans Scleroderma, Systemic/*etiology/immunology Vascular Diseases/complications
Pubmed
Création de la notice
25/01/2008 16:19
Dernière modification de la notice
20/08/2019 16:09
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